There are pain sensors spread throughout the human body; some are located under the skin, deep inside muscles, and on joints. When these sensors receive a big enough input, they open up and send a flood of positively-charged ions into the nerve, which transmits the pain sensation to the spinal cord and brain.

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The pain receptors can be activated from a number of different causes, from a fire hitting someone’s finger, to a dangerous chemical being dropped on a hand or leg, to hot coffee being spilled. All of these can result in pain due to mechanical, chemical, or temperature changes that affect the pain sensors.

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The brain, combined with the spinal cord, analyzes the messages sent from the pain receptors and determines whether or not there is a danger. If danger is sensed, then pain is the result, but if the inputs are not enough to result in pain, the brain does not transmit the message to shiledprotect} the body part.